BCL::Commons Academic License grants free access to this powerful open-source C++ library for biological molecule simulation, empowering researchers and educators at non-profit institutions to advance structural biology and drug discovery. Developed by Vanderbilt University's Meiler Lab, BCL::Commons delivers modular tools for protein structure determination from sparse data, small molecule alignment via BCL::MolAlign (outperforming tools like MOE and ROCS in pose recovery), fragment-based pharmacophore modeling, density map fitting for cryo-EM, and virtual high-throughput screening—streamlining workflows from ligand design to biomolecular prediction.
- Key Features: Object-oriented design for extensibility; applications like BCL::MolAlign for 3D ligand alignment; support for sparse experimental data in protein modeling; integration with cheminformatics for fragment libraries and neural network-based scoring.
- Educational Benefits: Ideal for academic research, teaching computational biology, and collaborative projects, with source code access for customization and community forums for troubleshooting.
- Usage: Non-commercial, non-profit use only; requires full-time academic affiliation verification via the online process.
To obtain your free academic license, complete the verification at meilerlab.org. For questions, contact the Meiler Lab team.